Hartley Guinea Pigs and Research Animals to Help Humanity

Characteristics of Guinea Pigs Which Enhance Their Use in Research
by Stacy Pritt, Elm Hill attending Veterinarian

1. Long Gestation Period with Mature Central Nervous System at Birth - Important for toxicology and teratology studies.
2. Sensitivity of Respiratory System - Important for asthma and environmental pollution studies.
3. Quiet, Calm Disposition - Important for entomology studies. Can be used to test repellents and insecticides, and as feeding source for biting insects.
4. Anatomy of the Guinea Pig Ear and Associated Structures - Important for Inner Ear Studies because it is easily dissected and exposed.
5. Vitamin C Requirement - Important for wound healing, as well as bone, tooth and atherosclerosis studies.
6. Guinea Pig Serum - Possesses Hemlytic Complement with Higher Activity Levels than Other Lab Animals. Widely used as a source of complement for complement fixation test.
7. Susceptibility to Infectious Diseases - Can be used as sentinel animals because of their acute susceptibility to Coxiella burnetii. Mycobacterium sp. Listeriosis.
8. Similar Immune System to Man - Guinea Pig immune system possesses a similar antigen-macrophage interaction to man and delayed cutaneous hypersensitivity reaction.
9. High Dietary Requirements - For folic acid, thiamin, arginine and potassium make guinea pigs useful in nutrition studies.

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